ParkinsonCanadaV1, Main, Exploration, bibRecord, 004222

Probing modifications of the neuronal cytoskeleton

Identifieur interne : 004222 ( Main/Exploration ); précédent : 004221; suivant : 004223

Probing modifications of the neuronal cytoskeleton

Auteurs : Laurie C. Doering [Canada]

Source :

Molecular Neurobiology [ 0893-7648 ] ; 1993-09-01.

RBID : ISTEX:702B80BB308643380B4F990F27EF0A00C7ED8C33

English descriptors

KwdEn :
- Aluminum (pharmacology), Alzheimer Disease (metabolism), Alzheimer Disease (pathology), Amyloid beta-Peptides (metabolism), Animals, Animals, Genetically Modified, Axons (metabolism), Brain Tissue Transplantation, Cytoskeletal Proteins (metabolism), Cytoskeleton (drug effects), Cytoskeleton (ultrastructure), Mammals, Mice, Nerve Degeneration, Nerve Tissue Proteins (metabolism), Neurons (drug effects), Neurons (pathology), Neurons (ultrastructure), Neurotoxins (pharmacology), PC12 Cells (transplantation), Parkinson Disease (metabolism), Parkinson Disease (pathology), Phosphorylation, Protein Processing, Post-Translational, Rats.
MESH :
- chemical , metabolism : Amyloid beta-Peptides, Cytoskeletal Proteins, Nerve Tissue Proteins.
- chemical , pharmacology : Aluminum, Neurotoxins.
- drug effects : Cytoskeleton, Neurons.
- metabolism : Alzheimer Disease, Axons, Parkinson Disease.
- pathology : Alzheimer Disease, Neurons, Parkinson Disease.
- transplantation : PC12 Cells.
- ultrastructure : Cytoskeleton, Neurons.
- Animals, Animals, Genetically Modified, Brain Tissue Transplantation, Mammals, Mice, Nerve Degeneration, Phosphorylation, Protein Processing, Post-Translational, Rats.

Abstract

Abstract: The prominent death of central neurons in Alzheimer's and Parkinson's is reflected by changes in cell shape and by the formation of characteristic cytoskeletal inclusions (neurofibrillary tangles, Lewy bodies). This review focuses on the biology of neurofilaments and microtubule-associated proteins and identifies changes that can occur to these elements from basic and clinical research perspectives. Attention is directed at certain advances in neurobiology that have been especially integral to the identification of epitope domains, protein isoforms, and posttranslational (phosphorylation) events related to the composition, development, and structure of the common cytoskeletal modifications. Recently, a number of experimental strategies have emerged to simulate the aberrant changes in neurodegenerative disorders and gain insight into possible molecular events that contribute to alterations of the cytoskeleton. Descriptions of specific systems used to induce modifications are presented. In particular, unique neural transplantation methods in animals have been used to probe possible molecular and cellular conditions concerned with abnormal cytoskeletal changes in neurons.

Url:

https://api-v5.istex.fr/document/702B80BB308643380B4F990F27EF0A00C7ED8C33/fulltext/pdf

DOI: 10.1007/BF02769179

Affiliations:

Le document en format XML

<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Probing modifications of the neuronal cytoskeleton</title>
<author><name sortKey="Doering, Laurie C" sort="Doering, Laurie C" uniqKey="Doering L" first="Laurie C." last="Doering">Laurie C. Doering</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:702B80BB308643380B4F990F27EF0A00C7ED8C33</idno>
<date when="1994" year="1994">1994</date>
<idno type="doi">10.1007/BF02769179</idno>
<idno type="url">https://api-v5.istex.fr/document/702B80BB308643380B4F990F27EF0A00C7ED8C33/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">002835</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002835</idno>
<idno type="wicri:Area/Istex/Curation">002835</idno>
<idno type="wicri:Area/Istex/Checkpoint">001B49</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001B49</idno>
<idno type="wicri:doubleKey">0893-7648:1994:Doering L:probing:modifications:of</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:8179841</idno>
<idno type="wicri:Area/PubMed/Corpus">001A01</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001A01</idno>
<idno type="wicri:Area/PubMed/Curation">001A01</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001A01</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001A01</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001A01</idno>
<idno type="wicri:Area/Ncbi/Merge">002466</idno>
<idno type="wicri:Area/Ncbi/Curation">002466</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">002466</idno>
<idno type="wicri:doubleKey">0893-7648::Doering L:probing:modifications:of</idno>
<idno type="wicri:Area/Main/Merge">004979</idno>
<idno type="wicri:Area/Main/Curation">004222</idno>
<idno type="wicri:Area/Main/Exploration">004222</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Probing modifications of the neuronal cytoskeleton</title>
<author><name sortKey="Doering, Laurie C" sort="Doering, Laurie C" uniqKey="Doering L" first="Laurie C." last="Doering">Laurie C. Doering</name>
<affiliation wicri:level="4"><country xml:lang="fr">Canada</country>
<wicri:regionArea>Division of Anatomy, Faculty of Health Sciences, McMaster University, L8N 3Z5, Hamilton, Ontarlo</wicri:regionArea>
<orgName type="university">Université McMaster</orgName>
<placeName><settlement type="city">Hamilton (Ontario)</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Molecular Neurobiology</title>
<title level="j" type="abbrev">Mol Neurobiol</title>
<idno type="ISSN">0893-7648</idno>
<idno type="eISSN">1559-1182</idno>
<imprint><publisher>Humana Press</publisher>
<pubPlace>Totowa</pubPlace>
<date type="published" when="1993-09-01">1993-09-01</date>
<biblScope unit="volume">7</biblScope>
<biblScope unit="issue">3-4</biblScope>
<biblScope unit="page" from="265">265</biblScope>
<biblScope unit="page" to="291">291</biblScope>
</imprint>
<idno type="ISSN">0893-7648</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0893-7648</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aluminum (pharmacology)</term>
<term>Alzheimer Disease (metabolism)</term>
<term>Alzheimer Disease (pathology)</term>
<term>Amyloid beta-Peptides (metabolism)</term>
<term>Animals</term>
<term>Animals, Genetically Modified</term>
<term>Axons (metabolism)</term>
<term>Brain Tissue Transplantation</term>
<term>Cytoskeletal Proteins (metabolism)</term>
<term>Cytoskeleton (drug effects)</term>
<term>Cytoskeleton (ultrastructure)</term>
<term>Mammals</term>
<term>Mice</term>
<term>Nerve Degeneration</term>
<term>Nerve Tissue Proteins (metabolism)</term>
<term>Neurons (drug effects)</term>
<term>Neurons (pathology)</term>
<term>Neurons (ultrastructure)</term>
<term>Neurotoxins (pharmacology)</term>
<term>PC12 Cells (transplantation)</term>
<term>Parkinson Disease (metabolism)</term>
<term>Parkinson Disease (pathology)</term>
<term>Phosphorylation</term>
<term>Protein Processing, Post-Translational</term>
<term>Rats</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Amyloid beta-Peptides</term>
<term>Cytoskeletal Proteins</term>
<term>Nerve Tissue Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Aluminum</term>
<term>Neurotoxins</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cytoskeleton</term>
<term>Neurons</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Alzheimer Disease</term>
<term>Axons</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Alzheimer Disease</term>
<term>Neurons</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="transplantation" xml:lang="en"><term>PC12 Cells</term>
</keywords>
<keywords scheme="MESH" qualifier="ultrastructure" xml:lang="en"><term>Cytoskeleton</term>
<term>Neurons</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Animals, Genetically Modified</term>
<term>Brain Tissue Transplantation</term>
<term>Mammals</term>
<term>Mice</term>
<term>Nerve Degeneration</term>
<term>Phosphorylation</term>
<term>Protein Processing, Post-Translational</term>
<term>Rats</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Abstract: The prominent death of central neurons in Alzheimer's and Parkinson's is reflected by changes in cell shape and by the formation of characteristic cytoskeletal inclusions (neurofibrillary tangles, Lewy bodies). This review focuses on the biology of neurofilaments and microtubule-associated proteins and identifies changes that can occur to these elements from basic and clinical research perspectives. Attention is directed at certain advances in neurobiology that have been especially integral to the identification of epitope domains, protein isoforms, and posttranslational (phosphorylation) events related to the composition, development, and structure of the common cytoskeletal modifications. Recently, a number of experimental strategies have emerged to simulate the aberrant changes in neurodegenerative disorders and gain insight into possible molecular events that contribute to alterations of the cytoskeleton. Descriptions of specific systems used to induce modifications are presented. In particular, unique neural transplantation methods in animals have been used to probe possible molecular and cellular conditions concerned with abnormal cytoskeletal changes in neurons.</div>
</front>
</TEI>
<affiliations><list><country><li>Canada</li>
</country>
<region><li>Ontario</li>
</region>
<settlement><li>Hamilton (Ontario)</li>
</settlement>
<orgName><li>Université McMaster</li>
</orgName>
</list>
<tree><country name="Canada"><region name="Ontario"><name sortKey="Doering, Laurie C" sort="Doering, Laurie C" uniqKey="Doering L" first="Laurie C." last="Doering">Laurie C. Doering</name>
</region>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004222 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 004222 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Canada
   |area=    ParkinsonCanadaV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     ISTEX:702B80BB308643380B4F990F27EF0A00C7ED8C33
   |texte=   Probing modifications of the neuronal cytoskeleton
}}

This area was generated with Dilib version V0.6.29.
Data generation: Thu May 4 22:20:19 2017. Site generation: Fri Dec 23 23:17:26 2022

La maladie de Parkinson au Canada (serveur d'exploration)

Probing modifications of the neuronal cytoskeleton

Probing modifications of the neuronal cytoskeleton

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	La maladie de Parkinson au Canada (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.